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Bone Marrow Failure syndromes (pilot)

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Presentation at a haematology clinic of an individual with haematological problems/neoplasia and a positive family history. NGS analysis of haematological samples for recurrent genomic abnormalities associated with inheritable bone marrow failure syndromes. For analysis of follow up germline samples, please see the Inherited cytopenias EQA.

EQA INFORMATION

EQA Code
HBMF
Submission
Clinical Report
Techniques
Next Generation Sequencing (NGS), Sanger sequencing, Whole genome analysis
Eligibility
All laboratories worldwide
Language
English, French, German, Italian, Polish, Portuguese, Spanish
EQA Accreditation
Pilot
EQA open

01 September 2026

Testing period
12 weeks

OTHER INFORMATION

What are participants required to do?
  • Enrolled participants will receive details by email when an EQA is open for assessment and/or samples have been dispatched.  
  • Participants are expected to access the instructions and information for the cases/samples online and to analyse them according to their laboratory/centre protocols. 
  • Participants must submit their anonymised results by the deadline using their standard laboratory report or a proforma provided by GenQA.  The submitted results are independently assessed for the accuracy of the analytical/genotyping results, clinical interpretation of the results (if appropriate) and clerical accuracy (including report layout and content). 

What can I expect as a participant?
Every participant will receive:
  • An Individual Laboratory/Centre Report (ILR/ICR) with educational advice for each distribution of this EQA.
  • The Summary report for each distribution of this EQA which contains information regarding general findings, a summary of methodologies used, common errors, number of participants and benchmarking. 
  • Access to a live Performance Certificate summarising your performance status for all EQAs in which you are enrolled.

Please note: EQA details may be subject to change prior to EQA distribution. 

PRODUCTS

Sample type: DNA in TE buffer
Testing/analysis:
  • NGS testing 
  • Single gene analysis
Conditions/Gene target(s):
  • Dyskeratosis congenita
  • Diamond Blackfan anaemia
  • Fanconi anaemia
  • Shwachman Diamond syndrome
  • Congenital thrombocytopenia
  • Neutropenia with a positive family history

We aim to include a variety of tests within each EQA.  You may opt out of any case if it is outside of your routine laboratory scope, by following the instructions in the EQA Distribution letter.
  
Number of cases: Two

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Bone Marrow Failure syndromes (pilot)

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