Details of the 2025 assessments can be found HERE. Run 14 is open for enrolment.  

This module provides an online competency assessment for the classification of BRCA and HRR (Homologous Recombination Repair) gene variants.  

Who can participate? 

All individuals who classify the pathogenicity of BRCA and other HRR gene variants.  

What is involved? 

For each assessment, participants receive 6 variants to classify within 4 weeks.  Participants can choose to classify some or all of the variants.   For each variant classification submitted, participants should also provide the criteria evidence for their classification.  

Information for participants:

Once registered, participants will receive:

1. Details of the next available assessment
2. Registration details for educational webinars. Webinars for previous assessments are freely available on the GenQA YouTube channel.

• ​Each asssessment includes BRCA1, BRCA2 and other HRR gene variants. 
• We suggest using either CanVIG-UK guidelines for Cancer Susceptibility Genes  or ClinGen VCEP guidelines for cancer susceptibility genes (BRCA1, BRCA2, ATM, PALB2).  
• The classifications and evidence are agreed by an international panel of experts and the classifications will be reviewed using these guidelines.

On completion of the assessment:

All participants will receive the following:

• Individual report which summarises their classification
• Summary report to enable benchmarking against the expert predicted classifications
• Certificate of participation

How do I enrol? 

• Enrolment for Run 14 will open on Monday 3rd March 2025.
• To enrol please click the blue button "ENROL NOW".
• There is no fee to participate in the BRCA/HRR classification module.

For further information please contact us at info@genqa.org

This educational content was co-developed and funded by AstraZeneca and MSD. The authors, reviewers, and editors of this material have made extensive efforts to ensure that the information is accurate and conforms to the standards accepted at the time of publication. However, constant changes in information resulting from continuing research and clinical experience, reasonable differences in opinions among authorities, unique aspects of individual clinical situations, and the possibility of human error in preparing materials mean that other sources of medical information may differ from the information on this site. The reader is advised to also consult local medical sources.

Z4-63360; Date of preparation: April 2024