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Classification of BRCA1, BRCA2 and other HRR gene variants module

The next assessment (Run 12) is now open until 30th April 2024.   


Full details can be found HERE


This module provides an online competency assessment for the classification of BRCA and HRR (Homologous Recombination Repair) gene variants.  


The assessments take place in spring and autumn of each year. 


Who can participate? 

All individuals who classify the pathogenicity of BRCA and other HRR gene variants.  


What is involved? 

For each assessment, participants receive 6 variants to classify within 4 weeks.  Participants can choose to classify some or all of the variants.   For each variant classification submitted, participants should also provide the criteria evidence for their classification.  


Information for participants:
  1.  Details of the next available assessment
  2. Registration details for educational webinars. Webinars for previous assessments are freely available on the GenQA YouTube channel.

*Run 11 will reference the recently published ClinGen ENIGMA BRCA1 and BRCA2 Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines Version 1.0.0.


On completion of the assessment:

All participants will receive the following:


How do I enrol? 

For further information please contact us at

Available globally

Participate multiple times throughout the year

Participant tailored assessment

Complete within 4 weeks

Access your EQA record any time through the GenQA website




Enrolment is now open for Run 12. 


The assessment is open until 30th April 2024.



Supported through an educational grant by:






This educational content was co-developed and funded by AstraZeneca and MSD. The authors, reviewers, and editors of this material have made extensive efforts to ensure that the information is accurate and conforms to the standards accepted at the time of publication. However, constant changes in information resulting from continuing research and clinical experience, reasonable differences in opinions among authorities, unique aspects of individual clinical situations, and the possibility of human error in preparing materials mean that other sources of medical information may differ from the information on this site. The reader is advised to also consult local medical sources.

Z4-63360; Date of preparation: April 2024