Gen QA

MEMBER LOGIN

MENU menu

Close close menu

EQA Genes

BACK TO EQA DIRECTORY

Genomic medicine is constantly evolving therefore if you do not find your gene of interest please contact info@genqa.org

 

Showing All Genes

ABCA3
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
ABCA4
Eye disorders (GEYE)
Molecular testing for retinopathies, structural eye disorders, optic atrophy, cataracts and albinism.
ABCB4
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
ACADM
Inborn Errors of Metabolism (IEM) (GIEM)
Molecular testing for IEM including MCAD deficiency, Fabry disease, Galactosaemia, Lysosomal storage disease, urea cycle defects.
ACTA2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
ACVRL1
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
AIP
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
AIRE
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
AKT1
Breast cancer (TBCP)
Molecular testing of breast cancers for PIK3CA and ESR1 variants in FFPE and cfDNA
ALK
Lung cancer - fusions (FISH/IHC) (TLFF)
Molecular testing using FISH/IHC of lung cancer: ALK, ROS1, MET and RET.
Lung cancer - fusions (molecular) (TLFM)
Molecular testing of lung cancer: ALK, ROS1, MET and RET.
ALPK3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
AP2S1
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
APC
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
APOB
Familial Hypercholesterolaemia (FH) (GFH)
Molecular testing for Familial hypercholesterolaemia.
APOE
Pharmacogenomics: APOE (pilot) (PGXE) NEW!
Molecular testing of the APOE gene.
APP
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
AR
Differences in Sex Development (DSD) (GDSD)
Molecular and cytogenomic testing for differences in sex development (DSD).
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
ATL1
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
ATM
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
ATN1
Huntington disease (HD) and DRPLA (GHD)
Molecular testing for Huntington disease and DRPLA.
ATP7B
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
ATR
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
ATXN1
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
ATXN2
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
ATXN3
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
ATXN7
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
BAG3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
BMPR2
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
BRAF
Colorectal cancer - core (TCRC)
Molecular testing of colorectal cancer: KRAS, NRAS and BRAF.
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
Melanoma (TM)
Molecular testing of melanoma.
Microsatellite instability testing (MSI) (TMSI)
Microsatellite instability testing (including BRAF and MLH1 promoter methylation if performed)
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
BRCA1
BRCA testing for ovarian and prostate cancer - somatic (TBS)
BRCA1 and BRCA2 testing and interpretation of results with respect to ovarian and prostate cancer.
BRCA testing for ovarian, breast, prostate and pancreatic cancer - germline (TBG)
BRCA1 and BRCA2 testing and interpretation in ovarian, breast, prostate and pancreatic cancer to determine treatment with PARP inhibitors - germline.
BRCA testing for prostate cancer - cfDNA (pilot) (TBP)
Somatic testing of homologous recombination repair genes in circulating tumour DNA for determination of treatment with PARP inhibitor therapy in prostate cancer.
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
BRCA2
BRCA testing for ovarian and prostate cancer - somatic (TBS)
BRCA1 and BRCA2 testing and interpretation of results with respect to ovarian and prostate cancer.
BRCA testing for ovarian, breast, prostate and pancreatic cancer - germline (TBG)
BRCA1 and BRCA2 testing and interpretation in ovarian, breast, prostate and pancreatic cancer to determine treatment with PARP inhibitors - germline.
BRCA testing for prostate cancer - cfDNA (pilot) (TBP)
Somatic testing of homologous recombination repair genes in circulating tumour DNA for determination of treatment with PARP inhibitor therapy in prostate cancer.
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
BRD4
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
BRIP1
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
BTK
Primary Immunodeficiency disorders (PID) (GPID)
Molecular testing for disorders associated with PID.
BUB1B
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
C9ORF72
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
CACNA1A
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
CASR
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
CCDC103
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
CCDC40
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
CDC73
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
CDCA7
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CDKN1B
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
CDKN1C
Imprinting disorders (GIM)
Molecular and cytogenomic testing for disorders associated with imprinting.
CENATAC
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CENPJ
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CEP152
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CEP295
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CEP57
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CEP63
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
CFTR
Cystic Fibrosis (CF) and CFTR-related disorders (GCF)
Molecular testing for cystic fibrosis (CF) and CFTR-related disorders. THIS EQA IS FULL. PLEASE CONTACT THE INFO@GENQA.ORG TO REGISTER.
Infertility (GINF)
Molecular and cytogenomic testing for infertility.
COL1A1
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
COL1A2
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
COL2A1
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
COL3A1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
COL4A3
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
COL4A4
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
COL4A5
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
COL5A1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
COL5A2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
CYBB
Primary Immunodeficiency disorders (PID) (GPID)
Molecular testing for disorders associated with PID.
CYP21A2
Differences in Sex Development (DSD) (GDSD)
Molecular and cytogenomic testing for differences in sex development (DSD).
CYP2B6
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
CYP2C19
Pharmacogenomics: CYP2C19 (PGXC)
Molecular testing of the CYP2C19 gene.
Updated with performance criteria
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
CYP2C9
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
CYP2D6
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
CYP3A5
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
DDIT3
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
DES
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
DMD
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
Muscular dystrophies (GMD)
Molecular testing for childhood-onset and adult-onset muscular dystrophies (including BMD/DMD).
DMPK
Hypotonic Infant (GHI)
Molecular and cytogenomic testing for DM1, PWS and SMA.
DNA2
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
DNAH11
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
DNAH5
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
DNAI1
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
DNMT3B
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
DPYD
Pharmacogenomics: DPYD (PGXD)
Molecular testing of the DPYD gene.
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
DSC2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
DSG2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
DSP
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
EGFR
Circulating free (cf) DNA testing in lung cancer (TCFD)
cfDNA testing for hotspot variants in lung cancer.
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
Lung cancer - EGFR only (TLE)
Molecular testing of lung cancer - EGFR testing only.
EMD
Muscular dystrophies (GMD)
Molecular testing for childhood-onset and adult-onset muscular dystrophies (including BMD/DMD).
ENG
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
ESCO2
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
ESR1
Breast cancer (TBCP)
Molecular testing of breast cancers for PIK3CA and ESR1 variants in FFPE and cfDNA
EWSR1
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
FAH
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
FANC genes
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
FBN1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
FGFR
Cholangiocarcinoma (TCC)
Molecular testing of IDH1 and FGFR rearrangements in cholangiocarcinoma
FGFR2
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
FGFR3
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
FH
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
FLCN
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
FLNC
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
FMR1
Fragile X syndrome and FMR1-related disorders (GFRAX)
Molecular testing for FMR1 (CGG)n repeats.
Infertility (GINF)
Molecular and cytogenomic testing for infertility.
FOXF1
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
FOXO1
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
FUS
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
FVL
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
FXN
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
GALT
Inborn Errors of Metabolism (IEM) (GIEM)
Molecular testing for IEM including MCAD deficiency, Fabry disease, Galactosaemia, Lysosomal storage disease, urea cycle defects.
GATA3
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
GCM2
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
GJB1
Charcot Marie Tooth disease (CMT) and related sensory and motor neuropathies (GCMT)
Molecular testing for Charcot Marie Tooth disease (CMT) and Hereditary Liability to Pressure Palsies (HNPP)
GLA
Inborn Errors of Metabolism (IEM) (GIEM)
Molecular testing for IEM including MCAD deficiency, Fabry disease, Galactosaemia, Lysosomal storage disease, urea cycle defects.
GNA11
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
GNAS
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
GRN
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
H19
Imprinting disorders (GIM)
Molecular and cytogenomic testing for disorders associated with imprinting.
HDAC8
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
HER2
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
HNF1B
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
HRAS
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
HTT
Huntington disease (HD) and DRPLA (GHD)
Molecular testing for Huntington disease and DRPLA.
ICR1
Imprinting disorders (GIM)
Molecular and cytogenomic testing for disorders associated with imprinting.
IDH1
Central Nervous System (CNS) tumours (TCNS)
Testing for 1p/19q co-deletion status and/or MGMT promotor methylation and/or IDH1/IDH2 status in CNS tumours.
Updated: In 2025, this EQA will include methylation profiling as an optional case.
Cholangiocarcinoma (TCC)
Molecular testing of IDH1 and FGFR rearrangements in cholangiocarcinoma
IDH2
Central Nervous System (CNS) tumours (TCNS)
Testing for 1p/19q co-deletion status and/or MGMT promotor methylation and/or IDH1/IDH2 status in CNS tumours.
Updated: In 2025, this EQA will include methylation profiling as an optional case.
IGHV
Chronic Lymphocytic Leukaemia (CLL) IGHV mutation status (HCLLI)
Analysis for IGHV mutation status in chronic lymphocytic leukaemia samples: DNA and lyophilised cells.
IL2RG
Primary Immunodeficiency disorders (PID) (GPID)
Molecular testing for disorders associated with PID.
JAZF1
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
KCNH2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
KCNQ1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
KCNQ1OT1
Imprinting disorders (GIM)
Molecular and cytogenomic testing for disorders associated with imprinting.
KEAP1
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
KIF1A
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
KIT
Gastrointestinal stromal tumours (GIST) (TGT)
Molecular testing of gastrointestinal stromal tumours: KIT and PDGFRA.
Melanoma (TM)
Molecular testing of melanoma.
KRAS
Circulating free (cf) DNA testing in lung cancer (TCFD)
cfDNA testing for hotspot variants in lung cancer.
Colorectal cancer - core (TCRC)
Molecular testing of colorectal cancer: KRAS, NRAS and BRAF.
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
LDLR
Familial Hypercholesterolaemia (FH) (GFH)
Molecular testing for Familial hypercholesterolaemia.
LMNA
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
Muscular dystrophies (GMD)
Molecular testing for childhood-onset and adult-onset muscular dystrophies (including BMD/DMD).
LOX
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
LZTR1
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
MAPT
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
MAX
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
MDM2
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
MECP2
Epilepsy disorders (GEP)
Molecular testing for disorders associated with early onset or syndromic epilepsy (including Rett syndrome, tuberous sclerosis and Dravet syndrome).
MEN1
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
MET
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
Lung cancer - fusions (FISH/IHC) (TLFF)
Molecular testing using FISH/IHC of lung cancer: ALK, ROS1, MET and RET.
Lung cancer - fusions (molecular) (TLFM)
Molecular testing of lung cancer: ALK, ROS1, MET and RET.
MFN2
Charcot Marie Tooth disease (CMT) and related sensory and motor neuropathies (GCMT)
Molecular testing for Charcot Marie Tooth disease (CMT) and Hereditary Liability to Pressure Palsies (HNPP)
MGMT
Central Nervous System (CNS) tumours (TCNS)
Testing for 1p/19q co-deletion status and/or MGMT promotor methylation and/or IDH1/IDH2 status in CNS tumours.
Updated: In 2025, this EQA will include methylation profiling as an optional case.
MLH1
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Endometrial tumours (TET)
Molecular testing of endometrial tumours: POLE, TP53, Microsatellite instability (MSI), MLH1 promoter methylation.
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
Microsatellite instability testing (MSI) (TMSI)
Microsatellite instability testing (including BRAF and MLH1 promoter methylation if performed)
MPZ
Charcot Marie Tooth disease (CMT) and related sensory and motor neuropathies (GCMT)
Molecular testing for Charcot Marie Tooth disease (CMT) and Hereditary Liability to Pressure Palsies (HNPP)
MSH2
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
MSH6
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
MT-ATP6
Mitochondrial disease (GMT)
Molecular testing for mitochondrial disease.
MT-RNR1
Pharmacogenomics: Aminoglycoside ototoxicity (PGXA)
Molecular testing of the MT-RNR1 gene.
MT-TL1
Mitochondrial disease (GMT)
Molecular testing for mitochondrial disease.
MUTYH
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
MYBPC3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
MYH7
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
MYL2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
MYLK
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
NF1
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
NF2
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
NIN
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
NIPBL
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
NR0B1
Differences in Sex Development (DSD) (GDSD)
Molecular and cytogenomic testing for differences in sex development (DSD).
NR4A3
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
NRAS
Colorectal cancer - core (TCRC)
Molecular testing of colorectal cancer: KRAS, NRAS and BRAF.
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Melanoma (TM)
Molecular testing of melanoma.
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
NSB1 (NBN)
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
NSMCE2
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
NTHL1
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
NTRK1
NTRK fusions (TNTRK)
Pan-cancer NTRK fusions testing in FFPE.
NTRK2
NTRK fusions (TNTRK)
Pan-cancer NTRK fusions testing in FFPE.
NTRK3
NTRK fusions (TNTRK)
Pan-cancer NTRK fusions testing in FFPE.
NUDT15
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
Pharmacogenomics: TPMT and NUDT15 (PGXT)
Molecular testing of the TPMT and NUDT15 genes.
OCA2
Eye disorders (GEYE)
Molecular testing for retinopathies, structural eye disorders, optic atrophy, cataracts and albinism.
OPA1
Eye disorders (GEYE)
Molecular testing for retinopathies, structural eye disorders, optic atrophy, cataracts and albinism.
PALB2
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
PAX6
Eye disorders (GEYE)
Molecular testing for retinopathies, structural eye disorders, optic atrophy, cataracts and albinism.
PDEAD
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
PDGFRA
Gastrointestinal stromal tumours (GIST) (TGT)
Molecular testing of gastrointestinal stromal tumours: KIT and PDGFRA.
PHOX2B
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
PIK3CA
Breast cancer (TBCP)
Molecular testing of breast cancers for PIK3CA and ESR1 variants in FFPE and cfDNA
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
PKD1
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
PKD2
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
PKHD1
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
PKP2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
PMP22
Charcot Marie Tooth disease (CMT) and related sensory and motor neuropathies (GCMT)
Molecular testing for Charcot Marie Tooth disease (CMT) and Hereditary Liability to Pressure Palsies (HNPP)
PMS2
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
POLD1
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
POLE
Colorectal cancer - MMR (MSI) (TCMMR)
Molecular testing of colorectal cancer: KRAS, NRAS, BRAF, MLH1, POLD1, POLE, PMS2, MSH2, MSH6, MSI and MLH1 promoter methylation.
Updated: The 2025 EQA will include the following additional genes: POLD1, MLH1, POLE, PMS2, MSH2 and MSH6
Endometrial tumours (TET)
Molecular testing of endometrial tumours: POLE, TP53, Microsatellite instability (MSI), MLH1 promoter methylation.
Familial colorectal cancer and polyposis (GCRC) Fully Booked
Molecular testing for Lynch syndrome, Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).
POLG
Mitochondrial disease (GMT)
Molecular testing for mitochondrial disease.
PRKAR1A
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
PRSS1
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
PTEN
Breast cancer (TBCP)
Molecular testing of breast cancers for PIK3CA and ESR1 variants in FFPE and cfDNA
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
PTH
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
PTPN11
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
RAD21
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
RAD51C
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
RAD51D
GENie BRCA and HRR gene variant classification assessment (BH)
Individual competency assessment for classification of BRCA1, BRCA2 and HRR gene variants, provided by the GenQA genomic education platform GENie.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
RBBP8
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
RBM20
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
RECQL3 (BLM)
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
REEP1
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
REN
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
RET
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
Lung cancer - fusions (FISH/IHC) (TLFF)
Molecular testing using FISH/IHC of lung cancer: ALK, ROS1, MET and RET.
Lung cancer - fusions (molecular) (TLFM)
Molecular testing of lung cancer: ALK, ROS1, MET and RET.
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
ROS1
Lung cancer - fusions (FISH/IHC) (TLFF)
Molecular testing using FISH/IHC of lung cancer: ALK, ROS1, MET and RET.
Lung cancer - fusions (molecular) (TLFM)
Molecular testing of lung cancer: ALK, ROS1, MET and RET.
RYR2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
SCN1A
Epilepsy disorders (GEP)
Molecular testing for disorders associated with early onset or syndromic epilepsy (including Rett syndrome, tuberous sclerosis and Dravet syndrome).
SCN5A
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
SDHA
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
SDHAF2
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
SDHB
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
SDHC
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
SDHD
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
SERPING1
Primary Immunodeficiency disorders (PID) (GPID)
Molecular testing for disorders associated with PID.
SFTPB
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
SFTPC
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
SLCO1B1
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
SMAD3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
SMAD4
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
SMARCB1
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
SMC1A
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
SMC3
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
SMN1
Hypotonic Infant (GHI)
Molecular and cytogenomic testing for DM1, PWS and SMA.
Spinal Muscular Atrophy (SMA) Molecular Newborn screening (bloodspots) (NBSS1)
Molecular testing of newborn screening cards for SMN1 deletions.
SMN2
Hypotonic Infant (GHI)
Molecular and cytogenomic testing for DM1, PWS and SMA.
SNRPN
Hypotonic Infant (GHI)
Molecular and cytogenomic testing for DM1, PWS and SMA.
SOD1
Neurodegenerative disorders (GND)
Molecular testing for dementia, Parkinson disease, Spinal Bulbar muscular atrophy and Amyotrophic lateral sclerosis (ALS).
SOX9
Skeletal dysplasia (including Osteogenesis Imperfecta) (GSKEL)
Molecular testing for FGFR2 and FGFR3-related disorders, osteogenesis imperfecta and other skeletal dysplasias.
SPAST
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
SPINK1
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
SPRED1
Neurofibromatosis and rasopathies (GNF)
Molecular testing for Neurofibromatosis type 1 / type 2 and Noonan syndrome.
SRD5A2
Differences in Sex Development (DSD) (GDSD)
Molecular and cytogenomic testing for differences in sex development (DSD).
SRY
Differences in Sex Development (DSD) (GDSD)
Molecular and cytogenomic testing for differences in sex development (DSD).
Infertility (GINF)
Molecular and cytogenomic testing for infertility.
SS18
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
STK11
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
TBCE
Parathyroid and Calcium Regulation disorders (GCAL)
Case scenario for hypercalcaemia and hypocalcaemia.
TBP
Ataxia & Hereditary Spastic Paraplegia (HSP) (GATAX)
Molecular testing for adult onset and childhood onset hereditary ataxias (including Friedreich ataxia, Spinocerebellar ataxia and hereditary spastic paraplegia).
TBX4
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
TERT
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
TFE3
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
TGFB3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TGFBG
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TGFBR1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TGFBR2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TMEM127
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
TNNI3
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TNNT2
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TP53
Chronic Lymphocytic Leukaemia (CLL) TP53 mutation analysis (HCLLT)
Analysis for TP53 mutation status in chronic lymphocytic leukaemia DNA samples.
Endometrial tumours (TET)
Molecular testing of endometrial tumours: POLE, TP53, Microsatellite instability (MSI), MLH1 promoter methylation.
Hereditary Breast and Ovarian Cancer (HBOC) disorders (GHBOC) Fully Booked
Molecular testing for disorders associated with HBOC.
Lung cancer - comprehensive (molecular) (TLCM)
Molecular testing of lung cancer for EGFR, KRAS, BRAF, MET (DNA only), HER2 (SNVs only), STK11, KEAP1, TP53 variants.
Thyroid cancer (TT)
Testing for somatic small nucelotide variants in thryoid cancer.
TPM1
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TPMT
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
Pharmacogenomics: TPMT and NUDT15 (PGXT)
Molecular testing of the TPMT and NUDT15 genes.
TRAIP
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
TRIP13
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.
TSC1
Epilepsy disorders (GEP)
Molecular testing for disorders associated with early onset or syndromic epilepsy (including Rett syndrome, tuberous sclerosis and Dravet syndrome).
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
TSC2
Epilepsy disorders (GEP)
Molecular testing for disorders associated with early onset or syndromic epilepsy (including Rett syndrome, tuberous sclerosis and Dravet syndrome).
Respiratory disorders (GRESP)
Molecular testing for pneumothorax, respiratory insufficiency / bronchiectasis (ciliopathies/PCD and surfactants), pulmonary arterial hypertension.
TTN
Cardiac disorders (GCARD)
Molecular testing for disorders associated with arrhythmia, cardiomyopathies and aortic dissection.
TYR
Eye disorders (GEYE)
Molecular testing for retinopathies, structural eye disorders, optic atrophy, cataracts and albinism.
UBE3A
Imprinting disorders (GIM)
Molecular and cytogenomic testing for disorders associated with imprinting.
UGT1A1
Gastroenterology and hepatology disorders (GGH)
Molecular testing for Hereditary Pancreatitis, Gilbert syndrome, Cholestasis, Hirschsprung disease, Polycystic liver disease and Intestinal failure.
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
UMOD
Renal disorders (GREN)
Molecular testing for haematuria, tubulointerstitial kidney disease, cystic renal disease, proteinuric renal disease and renal tubulopathies.
USP6
Sarcoma (TSA)
Testing for the detection of recurrent abnormalities associated with sarcomas in FFPE.
VHL
Familial endocrine tumour predisposition disorders (GEND)
Molecular testing for MEN1, MEN2, VHL and FMTC disorders.
VKORC1
Pharmacogenomics: panel (pilot) (PGXP)
Molecular testing of variants in common pharmacogenetics genes.
ZBTB24
Chromosome instability syndromes (GCI)
Molecular and/or cytogenomic testing for chromosome breakage or instability.